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Seminario do Bruce Weir, dia 13/03 as 16h
- Subject: Seminario do Bruce Weir, dia 13/03 as 16h
- From: Clarice Garcia Borges Demétrio <clarice.demetrio@usp.br>
- Date: Sat, 18 Feb 2012 12:05:56 -0200
Local: Departamento de Ciências Exatas, ESALQ/USP, Piracicaba
(visita programada por Carlos Alberto de Bragança Pereira, nosso amigo
Carlinhos do IME/USP)
"The heritability of human height." Bruce Weir, PhD
Professor and Chair, Department of Biostatistics
University of Washington
In 1886 Francis Galton published data on heights for people and their
parents. He showed that people's heights tended to be closer to the
population mean height than was the average of their parents' heights,
introducing the concept of "regression to the mean." He went on to
show that the relationship between the heights of pairs of people
depends on the degree of relatedness between the pair. His work was
replicated by Karl Pearson in 1903, three years after the rediscovery
of Mendel's Laws and "in the present controversial phase of the theory
of heredity." With the introduction of quantitative genetic models
(and the analysis of variance) by R.A. Fisher in 1918 we now express
the correlation in heights for pairs of people in terms of their
relatedness and the heritability of height. Heritability of a trait is
the portion of variance in trait values that has an (additive) genetic
component. By measuring heights on pairs of people of known family
relatedness, geneticists have estimated the heritability of human
height to be about 0.80. The recent flurry of genome-wide association
studies has revealed many genetic markers, SNPs, as-
sociated with height - a 2010 publication listed 135 from a
meta-analysis of 133,653 heights. However, these SNPs collectively
accounted for only 10% of the variation in height and the search began
for the "missing heritability." Using data from the GENEVA pro ject
that have been processed in our department, P.M. Visscher has extended
the early work of Galton, Pearson and Fisher by using all the SNPs
scored in a genome-wide scan, and by using measures of relatedness
estimated from these SNPs instead of being inferred from family
history. He could account for 45% of the variation. I will explain his
approach (Yang et al., Nature Genetics 43:519-525, 2011) and suggest
ways to account for the remaining 35%.
--
Bruce S. Weir
Professor and Chair, Department of Biostatistics
University of Washington
Seattle, WA 98195-7232
Phone (206) 221-7947. Fax (206) 543-3286.