Visita de Bruce Weir

[cpereira@ime.usp.br]

Aproveitando a deixa da Clarice anuncio aqui toda a programação da  
visita de Bruce Weir ao IME e aos departamentos de genética e  
estatística da ESALQ.  Ele vai estar trabalhando conosco em alguns  
projetos futuros.  Para que não conhece, Professor Weir é um dos mais  
importantes cientistas na área de genética estatística (ou estatística  
genética, como queiram). Ele estará nos visitando no período de 10 a  
18 de março. Aí está nossa programação

Carlinhos
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Dear All:
This seems to be the final schedule for Professor Weir visit.
I Hope everyone can participate in some of the activities I have  
programmed for him.
Best wishes
Carlos


Program for the Visit of Bruce Weir, Professor and Chair, of the  
Department of Biostatistics, University of Washington in Seattle.
1.     The abstracts of the conferences

Title of the 1st conference:

 ?The heritability of human height?
1.1  Abstract

In 1886 Francis Galton published data on heights for people and their  
parents. He showed that people?s heights tended to be closer to the  
population mean height than was the average of their parents? heights,  
introducing the concept of ?regression to the mean.? He went on to  
show that the relationship between the heights of pairs of people  
depends on the degree of relatedness between the pair. His work was  
replicated by Karl Pearson in 1903, three years after the rediscovery  
of Mendel?s Laws and ?in the present controversial phase of the theory  
of heredity.? With the introduction of quantitative genetic models  
(and the analysis of variance) by R.A. Fisher in 1918 we now express  
the correlation in heights for pairs of people in terms of their  
relatedness and the heritability of height. Heritability of a trait is  
the portion of variance in trait values that has an (additive) genetic  
component. By measuring heights on pairs of people of known family  
relatedness, geneticists have estimated the heritability of human  
height to be about 0.80. The recent flurry of genome-wide association  
studies has revealed many genetic markers, SNPs, as - associated with  
height ? a 2010 publication listed 135 from a meta-analysis of 133,653  
heights. However, these SNPs collectively accounted for only 10% of  
the variation in height and the search began for the ?missing  
heritability.? Using data from the GENEVA pro ject that have been  
processed in our department, P.M. Visscher has extended the early work  
of Galton, Pearson and Fisher by using all the SNPs scored in a  
genome-wide scan, and by using measures of relatedness estimated from  
these SNPs instead of being inferred from family history. He could  
account for 45% of the variation. I will explain his approach (Yang et  
al., Nature Genetics 43:519?525, 2011) and suggest ways to account for  
the remaining 35%.

Title of the 2nd conference:

?Somatic mosaicism for large chromosomal anomalies?
1.2  Abstract

Mosaics for large chromosomal anomalies (duplications, deletions and  
uniparental disomy) have been detected using SNP microarray data from  
over 50,000 subjects recruited for genome-wide association studies as  
part of the GENEVA Consortium. The frequency of chromosomal mosaicism  
in peripheral blood is low from birth until 50 years of age, after  
which it rises rapidly in the elderly. Many of the mosaic anomalies  
are characteristic of those found in hematological cancers and  
identify common deleted regions that pinpoint the locations of genes  
previously associated with hematological cancers.
The methodology used to detect these anomalies was developed for the  
GENEVA project by a team led by Dr. Cathy Laurie and will be discussed  
here. Results to be shown include those presented at the 2011  
International Congress of Human Genetics.



2.    The Week of Activities



1. 12/03/2012 - USP - Sao Paulo Statistics: "The heritability of human  
height."
2. 13/03/2012 ? USP ? Piracicaba Statistics: "The heritability of  
human height."
3. 14/03/2012 ? USP ? Piracicaba Genetics: "Somatic mosaicism for  
large chromosomal anomalies."
4. 15/03/2012 ? USP ? Sao Paulo Biology: "Somatic mosaicism for large  
chromosomal anomalies"

5. 16/03/2012 ? USP ? São Paulo Medicina: Discussion of research projects


I would like to remind you that on 18th of March starts our congress  
of Bayesian Analysis. It goes to March 22nd.

This is the biannual ISBrA (a Brazilian chapter of the international  
society for Bayeasian analysis) meeting.  The program and venue are  
superb.


http://www.brastex.info/ebeb2012/

O Símbolo da reunião é uma rede (nordestina) que denominamos rede Bayesiana.

Carlos Alberto de Braganca Pereira <cpereira@ime.usp.br>