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SeminÃrio
PIPGEs - UFSCar/USP Â 14/06/2013 - 14h00
LOCAL:
Sala 3-012 Â ICMC-USP TÃTULO: Designing a Cancer
Dose Finding Trial using EWOC NOME:
Andrà Rogatko -
Samuel Oschin Comprehensive Cancer Institute - USA RESUMO:
Escalation with
overdose control (EWOC) is a Bayesian adaptive dose finding design that produces
consistent sequences of doses while controlling the probability that patients
are overdosed. EWOC was the first dose-finding procedure to directly incorporate
the ethical constraint of minimizing the chance of treating patients at
unacceptably high doses. Its defining property is that the expected proportion
of patients treated at doses above the maximum tolerated dose (MTD) is equal to
a specified value Î, the feasibility bound. Among designs with this defining
property, EWOC minimizes the average amount by which patients are underdosed.
This means that EWOC approaches the MTD as rapidly as possible, while keeping
the expected proportion of patients overdosed less than the value Î. As a Trial
progresses, the dose sequence defined by EWOC approaches the MTD (i.e., the
sequence of recommended doses converges in probability to the MTD). Eventually,
all patients beyond a certain time would be treated at doses sufficiently close
to the MTD. Step-by-step instructions on how to design a trial using EWOC will
be discussed using the web application that can be accessed at |